The Horner Lab
Studying RNA Virus - Host Interactions
RNA Biology, Cell Biology, Antiviral Innate Immunity
Welcome to the Horner lab!
The overall goal of our research is to define the virus-host interactions that control the outcome of infection to hepatitis C virus and other Flaviviridae, including dengue virus and Zika virus. We hope to define the molecular mechanisms of how these viruses activate and evade host innate immune defenses, as well as RNA regulatory controls to viral infection and immunity. In particular, we are interested in the cell biological, post-translational, and post-transcriptional controls of innate immunity to RNA virus infection
Our lab is located at Duke University in the School of Medicine in Durham, NC in the Department of Integrative ImmunoBiology. We are members of the Center for RNA Biology, Center for Virology, Center for Host-Microbial Interactions, and Epigenetics & Epigenomics Program.
Recent Publications
Signaling from the RNA sensor RIG-I is regulated by ufmylation. doi: 10.1073/pnas.2119531119
WTAP Targets the METTL3 m6A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection. doi: 10.1128/jvi.00997-22
Flaviviridae Infection Alters m6A on Specific Cellular Transcripts. doi: 10.1016/j.molcel.2019.11.007
How RNA modifications regulate the antiviral response. doi: 10.1111/imr.13020
Post-Transcriptional Regulation of Antiviral Gene Expression by N6-Methyladenosine. doi: 10.1016/j.celrep.2021.108798
FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression. doi: 10.1016/j.jmb.2021.167247