Welcome to the Horner lab!

The overall goal of our research is to define the virus-host interactions that control the outcome of infection to hepatitis C virus and other Flaviviridae, including dengue virus and Zika virus. We hope to define the molecular mechanisms of how these viruses activate and evade host innate immune defenses, as well as RNA regulatory controls to viral infection and immunity. In particular, we are interested in the role that intracellular membranes play in organizing innate immune signaling platforms during RNA virus infection and how the RNA modification N6-methyladeonsine regulates Flaviviridae virus infection and antiviral innate immunity.

Our lab is located at the Duke University Medical Center in Durham, NC in the Department of Molecular Genetics and Microbiology. We often interact with our colleagues in the Center for Virology, Center for Host-Microbial Interactions, Center for RNA Biology, and Epigenetics & Epigenomics Program at Duke.


Recent Publications

RAB1B promotes antiviral innate immunity by interacting with TRAF3

New role for HCV NS4A protein in viral envelopment by interacting with E1

 

Review on regulation of viral infection by the RNA modification n6-methyladenosine

Book Chapter on methods to measure HCV envelopment